Measurement of metformin concentration in erythrocytes:clinical implications
Identifieur interne : 000E46 ( France/Analysis ); précédent : 000E45; suivant : 000E47Measurement of metformin concentration in erythrocytes:clinical implications
Auteurs : J. Lalau [France] ; C. Lacroix [France]Source :
- Diabetes, Obesity and Metabolism [ 1462-8902 ] ; 2003-03.
English descriptors
- KwdEn :
- Adult, Aged, Aged, 80 and over, Diabetes Mellitus, Type 2 (blood), Diabetes Mellitus, Type 2 (drug therapy), Erythrocytes (chemistry), Humans, Hypoglycemic Agents (blood), Hypoglycemic Agents (therapeutic use), Metformin (blood), Metformin (therapeutic use), Middle Aged, drug accumulation, erythrocyte, lactic acidosis, metformin, type 2 diabetes mellitus.
- MESH :
- chemical , blood : Hypoglycemic Agents, Metformin.
- blood : Diabetes Mellitus, Type 2.
- chemistry : Erythrocytes.
- drug therapy : Diabetes Mellitus, Type 2.
- chemical , therapeutic use : Hypoglycemic Agents, Metformin.
- Adult, Aged, Aged, 80 and over, Humans, Middle Aged.
Abstract
Aims: Although pharmacokinetics studies have long suggested a deep compartment for the antidiabetic drug metformin, there is still little information concerning metformin accumulation by individual tissues in man. In the present study, the erythrocyte was chosen to represent this putative deep compartment and metformin concentration in erythrocytes (EM) was compared with that in plasma (PM) to delineate clinical implications.
Url:
DOI: 10.1046/j.1463-1326.2003.00241.x
Affiliations:
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ISTEX:931735BFB107744C698612481435B9D4EC21768DLe document en format XML
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In the present study, the erythrocyte was chosen to represent this putative deep compartment and metformin concentration in erythrocytes (EM) was compared with that in plasma (PM) to delineate clinical implications.</div></front></TEI><affiliations><list><country><li>France</li></country><settlement><li>Le Havre</li></settlement></list><tree><country name="France"><noRegion><name sortKey="Lalau, J" sort="Lalau, J" uniqKey="Lalau J" first="J." last="Lalau">J. Lalau</name></noRegion><name sortKey="Lacroix, C" sort="Lacroix, C" uniqKey="Lacroix C" first="C." last="Lacroix">C. Lacroix</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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